Factors in the development of refractory primary open-angle glaucoma (part 1)

Primary open-angle glaucoma (POAG) is one of the most significant medico-social problems in modern society. The development its refractoriness aggravates pathological process and inevitably leads to blindness. Despite fact that this form accounts for up 80% all cases, problem POAG has not been considered sufficient detail either Russian or foreign sources. article presents an overview main ophthalmic factors contribute changes various structures eyeball accelerate formation refractory forms POAG. One reasons a genetic predisposition It worth noting 60% patients with family history glaucoma, risk developing increases by 10 times (among first-degree relatives). Additional are reactive syndrome during laser surgery. important emphasize progression hereditary much higher, while indicating number therapeutic measures may lead drug resistance. Genotyping promising scientific practical direction research, allowing prediction pharmacological response particular individual selection appropriate therapy according patient's genotype. This approach could help prevent complications improve accuracy disease prognosis.